You need a gateway to send your emails. You can select your gateways from MailGun, SMTP, Brevo, Amazon SES, SparkPost, SendGrid, PostMark, Elastic Email and PepiPost.
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Go to weMail→Settings→Email, you will find all the email gateways there. Just select any of the gateways with your API Key and go ahead with configuration.
Pick up your gateway to configure: